As they did previously with the first hotel, I assume they will be able to shift things around and fit them into the smaller available infield space. The biggest problem I can see is going to be that the new hotel construction will eliminate the present largest grandstand at Turn 11, which looks like it has almost half of the crowd.
https://hondaindy.com/festival/festivalmap
I think the best option to replace it would be to move or reduce the
Honda World area to put up some grandstands there at Turn 9 and 10.
After this past year, I wonder if they've been able to keep enough sponsors to break even. The races in
Vancouver and
Edmonton were both eventually going to have their sites become unavailable because of development, but the real reason both were discontinued was that they lost money, unable to attract enough corporate sponsorship to cover the cost of the event.